5 Hematopoietic regulation in inflammation滝澤 仁1) Kovtonyuk LV, Caiado F, Garcia-Martin S, et al. IL-1 mediates microbiome-induced inflammaging of hematopoietic stem cells in mice. Blood. 2022. 139(1):44-58.2) Wang Y, Morishima T, Sezaki M, et al. Akkermansia muciniphila induces slow extramedullary hematopoiesis via cooperative IL-1R/TLR signals. EMBO Rep. 2023. 24(12):e57485.3) Sezaki M, Hayashi Y, Nakato G, et al. Hematopoietic stem and progenitor cells integrate microbial signals to promote post-inflammation gut tissue repair. EMBO J. 2022. 41(22):e110712.4) Takizawa H, Fritsch K, Kovtonyuk LV, et al. Pathogen-induced TLR4-TRIF innate immune signaling in hematopoietic stem cells promotes proliferation but reduces competitive fitness. Cell Stem Cell. 2017. 21(2):225-240.熊本大学 国際先端医学研究機構 幹細胞ストレス講座2. 炎症における造血制御Hematopoiesis is a continuous blood production that is sustained by hematopoietic stem cells (HSCs), a somatic stem cell that lifelong selfrenew and differentiate into all blood and immune cells. When hematopoietic stress such as infection, inflammation, chemotherapy occur, HSC and progenitor function substantially change, i.e., attenuate HSC selfrenewal, bias their differentiation potential, etc. We have studied a role of innate immune signaling in HSCs and their offspring in the context of infection, inflammation and leukemogenesis, opening the field of stress hematopoiesis. More recently, we have found that microbial infiltration caused by tissue damage and natural aging, adapt hematopoiesis to enhance myelopoiesis, suggesting a crosstalk between gut and bone marrow which might serve as a tissue surveillance mechanism. I will discuss how to extrapolate from these findings development and maintenance of hemato-immune system throughout lifetime.International Research Center for Medical Sciences (IRCMS), Kumamoto UniversityHitoshi Takizawa
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