T1/ST2+CXCR3-正正常常Th2正正常常記記憶憶Th2（（生生体体防防御御免免疫疫・・抗抗体体））Allergen(Remodeling)IL-33RIL-7Pathogenic記記憶憶Th2細細胞胞IL-33RPathogenic記記憶憶Th2細細胞胞IL-7FibrosisOsteopontin2022 現在日日本本（（千千葉葉大大））米米国国（（シシアアトトルル））米米国国（（NIH））炎炎症症性性好好酸酸球球好好酸酸球球世世界界ででのの病病原原性性Th2細細胞胞のの報報告告Nakayama et al. Ann. Rev. Immunol35: 53 2017Endo et al Trends Immunol35:69 2014Endo et al. Immunity 35: 733 2011, 42: 294 2015Iinumaet al. Ann. Allergy Asthma Immunol114:289 2015Alyssa Mitson-Salazar et al. JACI137:907 2016 Eric Wambreet al. SciTrans Med 9:eaam9171 2017図図2図図11. Memory-type pathogenic Th2 (Tpath2) cellsMouse: CD44+CD62LloCXCR3loCCR4+CCR8+IL-7Raa+ST2+IL-17RB+CD4 T cellHuman ECRS: CD45RO+ST2+IL-17RB+CD4 T cell #Pathogenic Th disease induction model#Exacerbation by IL332. Pathogenic effector Th2 (peTh2) cells (C. Prussingroup, NIH)3. Pathogenic effector Th2 (Th2A) cells (Erik Wambre, BenaroyaRes Inst)Human (allergy to Alder tree pollen, Peanut, Dust mite/Cat, Timothy grass, Aspergillus)CCR7-CD7-CD27-CD45RB-CRTH2+CD161highCD49d+IL17RB+ST2+CD4 T cell #PGD2pathway: Cox2(PTGS2)hiPGDShiCRTH2+花花粉粉症症、、#activated by allergen, deleted by SLIT食食物物アアレレルルギギーー病病原原性性（（Pathogenic））記記憶憶Th2細細胞胞にによよるる気気道道炎炎症症・・線線維維化化AIRWAY好好酸酸球球性性副副鼻鼻腔腔炎炎好好酸酸球球性性食食道道炎炎Human EoE, AD:CD45RO+ CCR3+ CCR7-CD62Llo IL-7RaalowCRTH2+hPGDS+CD161highIL17RB+TSLPR+ST2+CD4 T cell #eosinophilia2022 現現在在Amphiregulin線線維維化化誘誘導導IL-5高高産産生生分分化化メメカカニニズズムム不不明明？？Chronic Airway InflammationIL-5図１ 世界での病原性Th2細胞の報告図2 病原性（Pathogenic）記憶Th2細胞による気道炎症・線維化14
元のページ ../index.html#17